Formation of nanoparticles of nonsteroidal anti-inflammatory drugs with metallographene structure and improved electrokinetic properties

Abstract

This monograph is a comprehensive guide to creating advanced functional nanomaterials based on oxidized graphene and copper, iron, copper/iron and zinc oxides complexed with some nonsteroidal anti-inflammatory drugs (ketorolac, diclofenac, acetylsalicylic and salicylic acids) by ultrasound (20 kHz). It is written with the aim to introduce a new concept of ultrasonic functionalization of pristine NSAIDs at the contact with metallographene nanoplatform to ameliorate the electronic molecular structure and electrokinetic properties of drugs as potential pharmaceutical NSAID-metallographene nanoparticles. The text includes the defined principles of formation and stability of final nanomaterials in aqueous solutions adjusted to pH=1, 5 and 8. Moreover, it shows the defined conditions of improved in vitro bacteriostatic and anticancer efficiency of formed NSAID-metallographene nanoparticles, e.g. with E.coli M-17 bacteria, and three cancer cell lines: HeLa (cervix), HepG2 (liver) and HT29 (colon) supported by the electroFenton cyclic voltammetry experiments of OH radical formation and inhibition. The reader can also find the discovered in vitro molecular switch in apoptosis of colon cancer cells HT29 by Fe3O4-rGO-SA nanoparticles in the addition of ascorbic acid in the frame of theoretically modeled H+ production on the surface of nanoparticles and their electromagnetic field distribution profile. This monograph is dedicated to the readears of the broad and multidisciplinary scientific community comprising of physicists and biophysicists, chemists and microbiologists working in the fields of nanoelectronics, nanomedicine and nanomaterials.