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Title: Sonochemical Formation of Copper/Iron-modified Graphene Oxide Nanocomposites for Ketorolac Delivery
Authors: Radziuk, D. V.
Mikhnavets, L. A.
Vorokhta, M.
Matolín, V.
Tabulina, L. V.
Labunov, V. A.
Keywords: публикации ученых;sonochemistry;graphene oxide;nanocomposite;NSAID;drug delivery
Issue Date: 2019
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
Citation: Sonochemical Formation of Copper/Iron-modified Graphene Oxide Nanocomposites for Ketorolac Delivery / Darya Radziuk, Lubov Mikhnavets, Mykhailo Vorokhta, Vladimнr Matolнn, Ludmila Tabulina, Vladimir Labunov // Chemistry – A European Journal. – 2019. – Vol. 25, Issue 24. – P. 6233-6245. – DOI: 10.1002/chem.201900662.
Abstract: A feasible sonochemical approach is described for the preparation of copper/iron-modified graphene oxide nanocomposites by using ultrasound (20 kHz, 18 W/cm2) in aqueous solution containing copper and iron ion precursors. Unique copper-, copper/iron- and iron-modified graphene oxide nanocomposites have a submicron size that is smaller than pristine GO and a higher surface area enriched with Cu2O, CuO, Fe2O3 of multiform phases (α-, β-, ε- or γ), FeO(OH) and sulfur- or carbon-containing compounds. These nanocomposites are sonochemically intercalated with the nonsteroidal anti-inflammatory drug ketorolac resulting in formation of nanoscale carriers. Ketorolac monotonically disintegrates from these nanoscale carriers in aqueous solution adjusted to pH from 1 to 8. The disintegration of ketorolac proceeds at a slower rate from the copper/iron-modified graphene oxide at increased pH, but at a faster rate from the iron-modified graphene oxide starting from acidic conditions.
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